The human plasminogen activator inhibitor type I gene promoter targets to kidney

The plasminogen activator inhibitor type 1 (PAI-1) gene encodes the physiological inhibitor of tissue-type and urokinase-type plasminogen activators and is induced by cytokines such as transforming growth factor-Beta (TGF-Beta). Studies have identified DNA sequence elements within the first 1.3 kb o...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 1998-02, Vol.43 (2), p.F405-F412
Main Authors: EMERT, M. P, SORENSON, C. M, BASILE, D. P, ROGERS, J. G, HAMMERMAN, M. R, BILLADELLO, J. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Deoxyribonucleic acid
DNA
Fundamental and applied biological sciences. Psychology
Gene expression
Genes
Kidneys
Molecular and cellular biology
Molecular genetics
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Summary:The plasminogen activator inhibitor type 1 (PAI-1) gene encodes the physiological inhibitor of tissue-type and urokinase-type plasminogen activators and is induced by cytokines such as transforming growth factor-Beta (TGF-Beta). Studies have identified DNA sequence elements within the first 1.3 kb of the 5'-upstream DNA that mediate cytokine responsiveness in transfected cells in vitro.
ISSN:1931-857X
1522-1466