Epidermal growth factor inhibits Na-Pi cotransport in weaned and suckling rats

In the present study, we determined the effect of epidermal growth factor (EGF; 10 mug/100 g body wt) on sodium gradient-dependent phosphate transport (Na-Pi cotransport) regulation in suckling (12-day-old) and weaned (24-day-old) rats. Weaned rats had higher proximal tubular brush border membrane v...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 1999, Vol.45 (1), p.F72-F78
Main Authors: ARAR, M, ZAJICEK, H. K, ELSHIHABI, I, LEVI, M, GONZALES, M, WILSON, P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell physiology
Fundamental and applied biological sciences. Psychology
Kidneys
Membrane and intracellular transports
Molecular and cellular biology
Peptides
Physical growth
Proteins
Rodents
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Summary:In the present study, we determined the effect of epidermal growth factor (EGF; 10 mug/100 g body wt) on sodium gradient-dependent phosphate transport (Na-Pi cotransport) regulation in suckling (12-day-old) and weaned (24-day-old) rats. Weaned rats had higher proximal tubular brush border membrane vesicle (BBMV) Na-Pi cotransport activity (232 +/- 16 in weaned vs. 130 +/- 9 pmol x 10s-1 x mg protein-1 in suckling rats, P < 0.05).
ISSN:1931-857X
1522-1466