Regulation of c-ret expression by retinoic acid in rat metanephros : implication in nephron mass control

Vitamin A and its derivatives have been shown to promote kidney development in vitro in a dose-dependent fashion. To address the molecular mechanisms by which all-trans-retinoic acid (RA) may regulate the nephron mass, rat kidneys were removed on embryonic day 14 (E14) and grown in organ culture und...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 1998-12, Vol.44 (6), p.938-945
Main Authors: MOREAU, E, VILAR, J, LELIEVRE-PEGORIER, M, MERLET-BENICHOU, C, GILBERT, T
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene expression
Kidneys
Molecular and cellular biology
Molecular genetics
Rodents
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Summary:Vitamin A and its derivatives have been shown to promote kidney development in vitro in a dose-dependent fashion. To address the molecular mechanisms by which all-trans-retinoic acid (RA) may regulate the nephron mass, rat kidneys were removed on embryonic day 14 (E14) and grown in organ culture under standard or RA-stimulated conditions.
ISSN:1931-857X
1522-1466