Acute-phase response protein serum amyloid A stimulates renal tubule formation: studies in vitro and in vivo

Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acute-phase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that fe...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2009-06, Vol.296 (6), p.F1355-F1363
Main Authors: Kelly, Katherine J, Kluve-Beckerman, Barbara, Dominguez, Jesus H
Format: Article
Language:English
Subjects:
Acute-Phase Reaction - chemically induced
Acute-Phase Reaction - metabolism
Animals
Biochemistry
Blood
Caseins - toxicity
Cell Line
Kidney - drug effects
Kidney - pathology
Kidney diseases
Kidney Tubules - drug effects
Kidney Tubules - growth & development
Kidneys
Mice
Mice, Inbred C57BL
Proteins
Rats
Serum Amyloid A Protein - metabolism
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Summary:Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acute-phase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule formation (in utero stage) and regeneration (recovery from ischemia-reperfusion injury). These data lend support to a novel view of a more localized renal acute-phase reaction, where renal SAA may act as a paracrine or autocrine molecule that promotes tubule formation during development and repair.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.90622.2008