Protection by Ethanolic Extract from Ulva lactuca L. against Acute Myocardial Infarction: Antioxidant and Antiapoptotic Activities

Reactive oxygen species (ROS) play a major role in myocardial damage during acute myocardial infarction (AMI). This study aimed to determine the antioxidant and antiapoptotic activities of an ethanolic extract from L. (EEUL) against AMI. Thirty-six male Wistar rats were divided into six groups: one...

Full description

Saved in:
Bibliographic Details
Published in:The Malaysian journal of medical sciences 2017-11, Vol.24 (6), p.39-49
Main Authors: Widyaningsih, Wahyu, Pramono, Suwidjiyo, Zulaela, Sugiyanto, Widyarini, Sitarina
Format: Article
Language:English
Subjects:
Algae
Animals
Antioxidants
Apoptosis
Flavonoids
Free radicals
Heart attacks
Identification
Laboratories
Melatonin
Oxidative stress
Phytochemicals
Rodents
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reactive oxygen species (ROS) play a major role in myocardial damage during acute myocardial infarction (AMI). This study aimed to determine the antioxidant and antiapoptotic activities of an ethanolic extract from L. (EEUL) against AMI. Thirty-six male Wistar rats were divided into six groups: one control group and five treatment groups. Treatment group II was given 85 mg/kg body weight (BW) of isoproterenol (ISO). Group III, IV and V were given ISO and EEUL at 250, 500 and 750 mg/kg BW, respectively. Group VI were given 10 mg/kg BW of ISO and melatonin. EEUL and melatonin were orally administered for 28 days. ISO was injected subcutaneously on day 29 and 30 to chemically induce AMI. On day 31, blood was collected for antioxidant assay and heart tissues were collected for histological examination. The activity of catalase (CAT), an endogenous antioxidant, in the EEUL-treatment groups was significantly increased compared to the ISO-treatment group ( < 0.001). The EEUL-treatment groups showed significantly decreased expression of caspase-3 ( < 0.001) and better myocardial tissue morphology. EEUL possibly protects against AMI because of its antioxidant and antiapoptotic properties.
ISSN:1394-195X
2180-4303
DOI:10.21315/mjms2017.24.6.5