C60 Fullerene with Tetraethylene Glycols as a Well-defined Soluble Building Block and Saccharide-conjugation Producing PDT Photosensitizer

Tetraethylene glycol (TEG)-conjugated (C60-Ih)[5,6]fullerene (TEG-C60) was synthesized as a soluble molecular building block generating C60-based conjugates with advanced properties. The improved solubility allowed the glycosylation reaction with TEG-C60 using a Lewis acid in chloroform at low tempe...

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Bibliographic Details
Published in:Chemistry letters 2019, Vol.48 (10), p.1209-1212
Main Authors: Narumi, Atsushi, Nakazawa, Tatsufumi, Shinohara, Kosuke, Kato, Hiroki, Iwaki, Yoshinori, Okimoto, Haruya, Kikuchi, Moriya, Kawaguchi, Seigou, Hino, Shodai, Ikeda, Atsushi, Montaser Shaykoon Ahmed Shaykoon, Shen, Xiande, Duan, Qian, Kakuchi, Toyoji, Yasuhara, Kazuma, Nomoto, Akihiro, Mikata, Yuji, Yano, Shigenobu
Format: Article
Language:English
Subjects:
Buckminsterfullerene
Carbohydrates
Chemical synthesis
Chloroform
Conjugation
Fullerenes
Lewis acid
Solubility
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Summary:Tetraethylene glycol (TEG)-conjugated (C60-Ih)[5,6]fullerene (TEG-C60) was synthesized as a soluble molecular building block generating C60-based conjugates with advanced properties. The improved solubility allowed the glycosylation reaction with TEG-C60 using a Lewis acid in chloroform at low temperature. The resultant glycoconjugated TEG-C60 was characterized in terms of water solubility, ability to generate reactive oxygen species (ROS), and photodynamic activity.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.190492