ANG II controls Na+-K+(NH4+)-2Cl- cotransport via 20-HETE and PKC in medullary thick ascending limb

Cell pH was monitored in medullary thick ascending limbs to determine effects ofANG II on Na+-K+(NH+4)-2Cl- cotransport. ANG II at 10-16 to 10-12 M inhibited 30-50% (P < 0.005), but higher ANG II concentrations were stimulatory compared with the 10-12 M ANG II level cotransport activity; eventual...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 1998-04, Vol.43 (4), p.C1047-C1056
Main Authors: AMLAL, H, LEGOFF, C, VERNIMMEN, C, SOLEIMANI, M, PAILLARD, M, BICHARA, M
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cell physiology
Cells
Fundamental and applied biological sciences. Psychology
Membrane and intracellular transports
Molecular and cellular biology
Proteins
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Summary:Cell pH was monitored in medullary thick ascending limbs to determine effects ofANG II on Na+-K+(NH+4)-2Cl- cotransport. ANG II at 10-16 to 10-12 M inhibited 30-50% (P < 0.005), but higher ANG II concentrations were stimulatory compared with the 10-12 M ANG II level cotransport activity; eventually, 10-6 M ANG II stimulated 34% cotransport activity (P < 0.003).
ISSN:0363-6143
1522-1563