Effects of aging on actin sliding speed on myosin from single skeletal muscle cells of mice, rats, and humans

The effect of aging on the mechanical properties of myosin were measured in 87 fibers from muscles of humans (n = 40), rates (n = 21), and mice (n = 26) using a single fiber in vitro motility assay. Irrespective of species, an 18-25% aging-related slowing in the speed of actin filaments were observe...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2001-04, Vol.49 (4), p.C782-C788
Main Authors: HÖÖK, Peter, SRIRAMOJU, Vidyasagar, LARSSON, Lars
Format: Article
Language:English
Subjects:
Aging
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Muscular system
Rodents
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:The effect of aging on the mechanical properties of myosin were measured in 87 fibers from muscles of humans (n = 40), rates (n = 21), and mice (n = 26) using a single fiber in vitro motility assay. Irrespective of species, an 18-25% aging-related slowing in the speed of actin filaments were observed from 62 single fibers expressing the slow (type I) beta-myosin heavy chain isoform.
ISSN:0363-6143
1522-1563