Characterization of osteoblast differentiation of stromal cell line ST2 that is induced by ascorbic acid

The stromal cell line ST2, derived from mouse bone marrow, differentiated into osteoblast-like cells in response to ascorbic acid. Ascorbic acid induced alkaline phosphatase (ALPase) activity, the expression of mRNAs for proteins that are markers of osteoblastic differentiation, the deposition of ca...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 1999-07, Vol.46 (1), p.C132
Main Authors: Otsuka, Eri, Yamaguchi, Akira, Hirose, Shigehisa, Hagiwara, Hiromi
Format: Article
Language:English
Subjects:
Bone marrow
Cellular biology
Proteins
Rodents
Vitamin C
Online Access:Get full text
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Summary:The stromal cell line ST2, derived from mouse bone marrow, differentiated into osteoblast-like cells in response to ascorbic acid. Ascorbic acid induced alkaline phosphatase (ALPase) activity, the expression of mRNAs for proteins that are markers of osteoblastic differentiation, the deposition of calcium, and the formation of mineralized nodules by ST2 cells.
ISSN:0363-6143
1522-1563