P2Z/P2X7 receptor-dependent apoptosis of dendritic cells

Macrophages and thymocytes express P2Z/P2X7 nucleotide receptors that bind extracellular ATP. These receptor play a role in immune development and control of microbial infections, but their presence on dendritic cells has not been reported.

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 1999-05, Vol.45 (5), p.C1139-C1147
Main Authors: COUTINHO-SILVA, R, PERSECHINI, P. M, DA CUNHA BISAGGIO, R, PERFETTINI, J.-L, TORRES DE SA NETO, A. C, KANELLOPOULOS, J. M, MOTTA-LY, I, DAUTRY-VARSAT, A, OJCIUS, D. M
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Monocytes, macrophages
Myeloid cells: ontogeny, maturation, markers, receptors
Ribonucleic acid
RNA
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Description
Summary:Macrophages and thymocytes express P2Z/P2X7 nucleotide receptors that bind extracellular ATP. These receptor play a role in immune development and control of microbial infections, but their presence on dendritic cells has not been reported.
ISSN:0363-6143
1522-1563