Protective role of HSP72 against Clostridium difficile toxin a-induced intestinal epithelial cell dysfunction

We determined whether the cytoprotective heat shock protein HSP72 protects against the injurious effects of Clostridium difficile toxin A (TxA) on intestinal epithelial cells. We conclude that HSP72 may protect intestinal epithelial cells from TxA-mediated damage through several mechanisms, includin...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2003-04, Vol.53 (4), p.C1073-C1082
Main Authors: LIU, Tom S, MUSCH, Mark W, SUGI, Kazunori, WALSH-REITZ, Margaret M, ROPELESKI, Mark J, HENDRICKSON, Barbara A, POTHOULAKIS, Charalabos, LAMONT, J. Thomas, CHANE, Eugene B
Format: Article
Language:English
Subjects:
Bacteria
Biological and medical sciences
Cells
Enzymes
Fundamental and applied biological sciences. Psychology
Intestine. Mesentery
Proteins
Small intestine
Vertebrates: digestive system
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Summary:We determined whether the cytoprotective heat shock protein HSP72 protects against the injurious effects of Clostridium difficile toxin A (TxA) on intestinal epithelial cells. We conclude that HSP72 may protect intestinal epithelial cells from TxA-mediated damage through several mechanisms, including actin stabilization, mitochondrial protection, and inhibition of apoptosis activation, but not by prevention of RhoA glucosylation. [PUBLICATION ABSTRACT]
ISSN:0363-6143
1522-1563