Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle

Calcineurin mediates repression of plasma membrane Ca2+-ATPase-4 (PMCA4) expression in neurons, whereas c-Myb is known to repress PMCA1 expression in vascular smooth muscle cells (VSMC). Data show that G1/S-specific PMCA4 repression in proliferating VSMC is brought about by c-Myb and CaMK-II and tha...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2003-07, Vol.54 (1), p.C88-C95
Main Authors: AFROZE, Talat, YANG, Li L, CHANGSEN WANG, GROS, Robert, KALAIR, Waseem, HOQUE, Abu N, MUNGRUE, Imran N, ZIPING ZHU, HUSAIN, Mansoor
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood vessels and receptors
Calcium
Cellular biology
Fundamental and applied biological sciences. Psychology
Membranes
Plasma
Vertebrates: cardiovascular system
Online Access:Get full text
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Summary:Calcineurin mediates repression of plasma membrane Ca2+-ATPase-4 (PMCA4) expression in neurons, whereas c-Myb is known to repress PMCA1 expression in vascular smooth muscle cells (VSMC). Data show that G1/S-specific PMCA4 repression in proliferating VSMC is brought about by c-Myb and CaMK-II and that calcineurin may regulate cell cycle-associated [Ca2+]i through alternate targets. [PUBLICATION ABSTRACT]
ISSN:0363-6143
1522-1563