Genistein activates CFTR-mediated Cl- secretion in the murine trachea and colon

The action of the isoflavone genistein on the cystic fibrosis transmembrane conductance regulator (CFTR) has been studied in many cell systems but not in intact murine tissues. We have investigated the action of genistein on murine tissues from normal and cystic fibrosis (CF) mice.

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2000-08, Vol.48 (2), p.383-392
Main Authors: GODDARD, C. A, EVANS, M. J, COLLEDGE, W. H
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Biology
Cell physiology
Colon
Cystic fibrosis
Fundamental and applied biological sciences. Psychology
Genetics
Membrane and intracellular transports
Molecular and cellular biology
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Description
Summary:The action of the isoflavone genistein on the cystic fibrosis transmembrane conductance regulator (CFTR) has been studied in many cell systems but not in intact murine tissues. We have investigated the action of genistein on murine tissues from normal and cystic fibrosis (CF) mice.
ISSN:0363-6143
1522-1563