Phosphatidylinositol 3-kinase-dependent stabilization of alpha1(I) collagen mRNA in human lung fibroblasts

We investigated the role of phosphatidylinositol 3-kinase (PI3K) in the expression of alpha1(I) collagen mRNA. We report that the basal level of alpha1(I) collagen mRNA was reduced when PI3K activity was inhibited by either LY-294002 or wortmannin.

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2001-07, Vol.50 (1), p.C99
Main Authors: Ricupero, Dennis A, Poliks, Christine F, Rishikof, David C, Cuttle, Kelly A
Format: Article
Language:English
Subjects:
Biochemistry
Lungs
Ribonucleic acid
RNA
Online Access:Get full text
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Description
Summary:We investigated the role of phosphatidylinositol 3-kinase (PI3K) in the expression of alpha1(I) collagen mRNA. We report that the basal level of alpha1(I) collagen mRNA was reduced when PI3K activity was inhibited by either LY-294002 or wortmannin.
ISSN:0363-6143
1522-1563