Bioactive products of arginine in sepsis : tissue and plasma composition after LPS and iNOS blockade

Blockade or gene deletion of inducible nitric oxide synthase (iNOS) fails to fully abrogate all the sequelae leading to the high morbidity of septicemia. An increase in skustrate uptake may be necessary for the increased production of nitric oxide (NO), but arginine is also a precursor for other bio...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2000-06, Vol.47 (6), p.C1191-C1199
Main Authors: LORTIE, M. J, ISHIZUKA, S, SCHWARTZ, D, BLANTZ, R. C
Format: Article
Language:English
Subjects:
Anatomy & physiology
Animal bacterial diseases
Bacterial diseases
Biological and medical sciences
Cellular biology
Infectious diseases
Medical sciences
Plasma
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Summary:Blockade or gene deletion of inducible nitric oxide synthase (iNOS) fails to fully abrogate all the sequelae leading to the high morbidity of septicemia. An increase in skustrate uptake may be necessary for the increased production of nitric oxide (NO), but arginine is also a precursor for other bioactive products.
ISSN:0363-6143
1522-1563