Inhibition of TASK-1 potassium channel by phospholipase C

The two-pore-domain K+ channel, TASK-1, was recently shown to be a target of receptor-mediated regulation in neurons and in adrenal glomerulosa cells. Here, we demonstrate that TASK-1 expressed in Xenopus laevis oocytes is inhibited by different Ca2+-mobilizing agonists.

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2001-08, Vol.50 (2), p.C700-C708
Main Authors: CZIRJAK, Gabor, PETHEO, Gabor L, SPAT, Andras, ENYEDI, Peter
Format: Article
Language:English
Subjects:
Adrenal glands
Biological and medical sciences
Cell membranes. Ionic channels. Membrane pores
Cell structures and functions
Cells
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Neurons
Potassium
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Description
Summary:The two-pore-domain K+ channel, TASK-1, was recently shown to be a target of receptor-mediated regulation in neurons and in adrenal glomerulosa cells. Here, we demonstrate that TASK-1 expressed in Xenopus laevis oocytes is inhibited by different Ca2+-mobilizing agonists.
ISSN:0363-6143
1522-1563