Developmental changes in ryanodine- and IP3-sensitive Ca2+ pools in ovine basilar artery

To explore the hypothesis that cerebrovascular maturation alters ryanodine- and inositol 1,4,5-trisphosphate (IP3)-sensitive Ca2+ pool sizes, we measured total intracellular Ca2+ with (45)Ca and the fractions of intracellular Ca2+ released by IP3 and/or caffeine in furaptra-loaded permeabilized basi...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2001-12, Vol.50 (6), p.C1785-C1796
Main Authors: NAULI, S. M, WILLIAMS, J. M, AKOPOV, S. E, ZHANG, L, PEARCE, W. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain
Calcium
Cell physiology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Muscle contraction
Sheep
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Summary:To explore the hypothesis that cerebrovascular maturation alters ryanodine- and inositol 1,4,5-trisphosphate (IP3)-sensitive Ca2+ pool sizes, we measured total intracellular Ca2+ with (45)Ca and the fractions of intracellular Ca2+ released by IP3 and/or caffeine in furaptra-loaded permeabilized basilar arteries from nonpregnant adult and term fetal (139-141 days) sheep.
ISSN:0363-6143
1522-1563