Characterization of a novel 132-bp exon of the human maxi-K channel

The large-conductance Ca2+-activated voltage-dependent K+ channel (maxi-K channel) induces a significant repolarizing current that buffers cell excitability. This channel can derive its diversity by alternative splicing of its transcript-producing isoforms that differ in their sensitivity to voltage...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2001-07, Vol.50 (1), p.C361-C367
Main Authors: KOROVKINA, Victoria P, FERGUS, Daniel J, HOLDIMAN, Amanda J, ENGLAND, Sarah K
Format: Article
Language:English
Subjects:
Biochemistry
Biological and medical sciences
Calcium
Cell membranes. Ionic channels. Membrane pores
Cell structures and functions
Cells
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Potassium
Tissues
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Summary:The large-conductance Ca2+-activated voltage-dependent K+ channel (maxi-K channel) induces a significant repolarizing current that buffers cell excitability. This channel can derive its diversity by alternative splicing of its transcript-producing isoforms that differ in their sensitivity to voltage and intracellular Ca2+.
ISSN:0363-6143
1522-1563