PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle

Regulation of adenylyl cyclase type V/VI and cAMP-specific,GMP-inhibited phosphodiesterase (PDE) 3 and cAMP-specific PDE4 by cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) was examined in gastric smooth muscle cells. Expression of PDE3A but not PDE3B was demonstrated by...

Full description

Saved in:
Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2002-03, Vol.51 (3), p.C508-C517
Main Authors: MURTHY, Karnam S, HUIPING ZHOU, MAKHLOUF, Gabriel M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell physiology
Cells
Digestive system
Enzymes
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Muscle contraction
Muscular system
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Regulation of adenylyl cyclase type V/VI and cAMP-specific,GMP-inhibited phosphodiesterase (PDE) 3 and cAMP-specific PDE4 by cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) was examined in gastric smooth muscle cells. Expression of PDE3A but not PDE3B was demonstrated by RT-PCR and Western blot.
ISSN:0363-6143
1522-1563