Differential expression of TGF-β isoforms by normal and inflammatory bowel disease intestinal myofibroblasts

Intestinal strictures are frequent in Crohn's disease but not ulcerative colitis. We investigated the expression of transforming growth factor (TGF)-beta isoforms by isolated and cultured primary human intestinal myofibroblasts and the responsiveness of these cells and intestinal epithelial cel...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2002, Vol.51 (1), p.C172-C182
Main Authors: MCKAIG, B. C, HUGHES, K, TIGHE, P. J, MAHIDA, Y. R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bowel disease
Cells
Gastroenterology. Liver. Pancreas. Abdomen
Medical sciences
Other diseases. Semiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Intestinal strictures are frequent in Crohn's disease but not ulcerative colitis. We investigated the expression of transforming growth factor (TGF)-beta isoforms by isolated and cultured primary human intestinal myofibroblasts and the responsiveness of these cells and intestinal epithelial cells to TGF-beta isoforms.
ISSN:0363-6143
1522-1563