Does Subclinical Hypothyroidism Explain the Increased Susceptibility of Women to Torsades de Pointes?

Among 20 consecutive patients (65% women) with drug-associated torsades de pointes, chemical evidence for hypothyroidism was found in only 10% of both women and men. Subclinical hypothyroidism is therefore unlikely to account for the consistently observed sex difference in the propensity to torsades...

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Bibliographic Details
Published in:The American journal of cardiology 1997-04, Vol.79 (7), p.963-965
Main Authors: Lehmann, Michael H., Frankovich, Debra, Baga, John J., Pires, Luis A., Schuger, Claudio D., Steinman, Russell T., Rabinowe, Steven L.
Format: Article
Language:English
Subjects:
Aged
Anti-Arrhythmia Agents - adverse effects
Anti-Arrhythmia Agents - therapeutic use
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Cardiovascular disease
Disease Susceptibility
Electrocardiography
Female
Heart
Humans
Hypothyroidism - complications
Hypothyroidism - diagnosis
Hypothyroidism - epidemiology
Male
Medical research
Medical sciences
Risk Factors
Sex Factors
Sexes
Thyroid gland
Torsades de Pointes - chemically induced
Torsades de Pointes - epidemiology
Torsades de Pointes - etiology
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Summary:Among 20 consecutive patients (65% women) with drug-associated torsades de pointes, chemical evidence for hypothyroidism was found in only 10% of both women and men. Subclinical hypothyroidism is therefore unlikely to account for the consistently observed sex difference in the propensity to torsades de pointes.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00022-2