Inhaled nitric oxide in children with pulmonary hypertension and congenital mitral stenosis

We demonstrated selective pulmonary vasodilation in patients with congenital mitral stenosis with inhaled NO, and used NO as prolonged therapy to stabilize the postintervention course of these children. The pulmonary vasoreactivity was greater than that previously reported in adults and may be due t...

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Bibliographic Details
Published in:The American journal of cardiology 1996-02, Vol.77 (4), p.316-319
Main Authors: Atz, Andrew M., Adatia, Ian, Jonas, Richard A., Wessel, David L.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adolescent
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Child
Child, Preschool
Children & youth
Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
Female
Heart
Humans
Hypertension
Hypertension, Pulmonary - drug therapy
Hypertension, Pulmonary - etiology
Infant
Male
Medical sciences
Mitral Valve Stenosis - complications
Mitral Valve Stenosis - congenital
Nitric Oxide - administration & dosage
Nitric Oxide - therapeutic use
Pediatrics
Pulmonary Circulation - drug effects
Pulmonary Wedge Pressure - drug effects
Vascular Resistance - drug effects
Vasodilation - drug effects
Vasodilator Agents - administration & dosage
Vasodilator Agents - therapeutic use
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Description
Summary:We demonstrated selective pulmonary vasodilation in patients with congenital mitral stenosis with inhaled NO, and used NO as prolonged therapy to stabilize the postintervention course of these children. The pulmonary vasoreactivity was greater than that previously reported in adults and may be due to particular sensitivity of pulmonary veins to inhaled NO when pulmonary venous hypertension has been present since birth.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)89404-0