Frequency of Sudden Cardiac Death and Profiles of Risk

The epidemiology of ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) must be explored from multiple aspects, each of which contributes insights into the problem and no one of which exerts exclusive dominance for preventive or therapeutic strategies. These include: (1) popu...

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Bibliographic Details
Published in:The American journal of cardiology 1997-09, Vol.80 (5), p.10F-19F
Main Authors: Myerburg, Robert J, Interian, Alberto, Mitrani, Raul M, Kessler, Kenneth M, Castellanos, Agustin
Format: Article
Language:English
Subjects:
Adult
Age
Anti-Arrhythmia Agents - adverse effects
Biological and medical sciences
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology. Vascular system
Cardiovascular disease
Coronary Disease - epidemiology
Death & dying
Death, Sudden, Cardiac - epidemiology
Disease prevention
Disease Susceptibility
Efficiency
Epidemiology
Fatalities
Female
Follow-Up Studies
Heart
Heart attacks
Heart failure
Humans
Incidence
Intervention
Male
Medical sciences
Mens health
Middle Aged
Mortality
Population
Population Dynamics
Prevalence
Preventive medicine
Public health
Risk Assessment
Risk Factors
Tachycardia, Ventricular - epidemiology
Tachycardia, Ventricular - etiology
Torsades de Pointes - chemically induced
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Description
Summary:The epidemiology of ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) must be explored from multiple aspects, each of which contributes insights into the problem and no one of which exerts exclusive dominance for preventive or therapeutic strategies. These include: (1) population dynamics, using conventional epidemiologic approaches; (2) risk as a function of time from an index event; (3) conditioning risk factors, based on the presence of underlying disease states; (4) transient risk factors that are dynamic and trigger a potentially fatal event at a specific point in time; and (5) “response risk,” which refers to individual susceptibility (possibly determined genetically) to the adverse effects of longitudinal and/or dynamic risk factors. Major inroads into profiling individual or population risk of SCD will require better understanding of each of these epidemiologic-clinical-physiologic interactions. The disciplines range from epidemiology, through clinical medicine, to membrane channel physiology, genetic determinants, and molecular biology.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00477-3