Comparison of survival and other complications after heart transplantation in patients taking amiodarone before surgery versus those not taking amiodarone

Concern exists regarding preoperative amiodarone use and complications occurring after heart transplantation (HT). During a 10-year period of performing HT, we found that patients treated with amiodarone before undergoing HT had decreased overall survival, required longer periods of ventilatory supp...

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Bibliographic Details
Published in:The American journal of cardiology 2004-02, Vol.93 (3), p.379-381
Main Authors: Blomberg, Patrick J., Feingold, Andrew D., Denofrio, David, Rand, William, Konstam, Marvin A., Estes, N.A.Mark, Link, Mark S.
Format: Article
Language:English
Subjects:
Adult
Aged
Amiodarone - adverse effects
Cardiology
Drug therapy
Female
Heart
Heart Failure - mortality
Heart Failure - therapy
Heart Transplantation
Humans
Male
Middle Aged
Postoperative Complications
Retrospective Studies
Survival Rate
Transplants & implants
Vasodilator Agents - adverse effects
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Description
Summary:Concern exists regarding preoperative amiodarone use and complications occurring after heart transplantation (HT). During a 10-year period of performing HT, we found that patients treated with amiodarone before undergoing HT had decreased overall survival, required longer periods of ventilatory support, and were at increased risk for significant bleeding complications. These findings raise further concern about the use of amiodarone treatment in patients with heart failure before undergoing HT.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2003.10.027