Relation of stent design and stent surface material to subsequent in-stent intimal hyperplasia in coronary arteries determined by intravascular ultrasound

A variety of different stent designs and coatings have become available. This study sought to determine the impact of stent design and gold-coating of stents on intimal hyperplasia (IH) in human atherosclerotic coronary arteries in relation to known predictors of restenosis. Angiographic and intrava...

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Bibliographic Details
Published in:The American journal of cardiology 2002-06, Vol.89 (12), p.1360-1364
Main Authors: Hoffmann, Rainer, Mintz, Gary S, Haager, Philipp K, Bozoglu, Togul, Grube, Eberhard, Gross, Michael, Beythien, Christian, Mudra, Harald, vom Dahl, Jürgen, Hanrath, Peter
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Chi-Square Distribution
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - pathology
Coronary Artery Disease - therapy
Coronary vessels
Coronary Vessels - diagnostic imaging
Coronary Vessels - pathology
Diseases of the cardiovascular system
Endosonography
Equipment Design
Female
Gold - adverse effects
Humans
Hyperplasia - diagnostic imaging
Male
Medical sciences
Middle Aged
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Recurrence
Risk Factors
Stents
Stents - adverse effects
Tunica Intima - pathology
Ultrasonic imaging
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Summary:A variety of different stent designs and coatings have become available. This study sought to determine the impact of stent design and gold-coating of stents on intimal hyperplasia (IH) in human atherosclerotic coronary arteries in relation to known predictors of restenosis. Angiographic and intravascular ultrasound (IVUS) studies were performed at 6-month follow-up on 311 native coronary lesions of 311 patients treated with 99 Multi-Link stents, 74 InFlow steel stents, 73 InFlow gold-coated stents, 41 Palmaz-Schatz stents, 12 NIR steel stents, and 12 gold-coated NIR Royal stents. Lumen and stent cross-sectional area (CSA) were measured at 1-mm axial increments. Mean IH CSA (stent CSA − lumen CSA) and mean IH thickness were calculated and averaged over the total stent length. IVUS demonstrated different levels of IH for the 6 stents. Mean IH thickness ranged from 0.20 ± 0.13 mm for Multi-Link stents to 0.43 ± 0.14 mm for InFlow goal-coated stents (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(02)02347-0