Efficacy and safety of intravenous dofetilide for rapid termination of atrial fibrillation and atrial flutter

Dofetilide may be advantageous in terminating atrial fibrillation/atrial flutter (AFl) when there are contraindications for class I drugs (left ventricular dysfunction and/or manifest myocardial ischemia) and beta blockers. In particular, its successful outcome in usually drug-resistant AFl is promi...

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Bibliographic Details
Published in:The American journal of cardiology 2000-04, Vol.85 (8), p.1031-1033
Main Authors: Lindeboom, Jan-Eize, Kingma, J.Herre, Crijns, Harry J.G.M., Dunselman, Peter H.J.M.
Format: Article
Language:English
Subjects:
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - therapeutic use
Antiarythmic agents
Atrial Fibrillation - drug therapy
Atrial Flutter - drug therapy
Biological and medical sciences
Cardiac arrhythmia
Cardiology
Cardiovascular system
Clinical trials
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Infusions, Intravenous
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Phenethylamines - administration & dosage
Phenethylamines - therapeutic use
Potassium Channel Blockers
Safety
Sulfonamides - administration & dosage
Sulfonamides - therapeutic use
Time Factors
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Description
Summary:Dofetilide may be advantageous in terminating atrial fibrillation/atrial flutter (AFl) when there are contraindications for class I drugs (left ventricular dysfunction and/or manifest myocardial ischemia) and beta blockers. In particular, its successful outcome in usually drug-resistant AFl is promising and underscores the importance of selective class III action for terminating AFl.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00927-3