Fatal pulmonary toxicity occurring within two weeks of initiation of amiodarone

We report the case of a patient who was treated with amiodarone, developed an acute pneumonitis within 2 weeks, and succumbed to fatal pulmonary fibrosis despite treatment with corticosteriods. As the use of amiodarone expands, all physicians must be aware of the potential for amiodarone-related pul...

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Bibliographic Details
Published in:The American journal of cardiology 2002-04, Vol.89 (7), p.896-898
Main Authors: Kharabsheh, Suleiman, Abendroth, Catherine S., Kozak, Mark
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Amiodarone - administration & dosage
Amiodarone - adverse effects
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - adverse effects
Biological and medical sciences
Cardiology
Drug Administration Schedule
Drug toxicity and drugs side effects treatment
Fatal Outcome
Fatalities
Humans
Lung - drug effects
Lung - pathology
Male
Medical sciences
Pharmacology. Drug treatments
Pneumonia - chemically induced
Pneumonia - diagnosis
Pneumonia - pathology
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - diagnosis
Pulmonary Fibrosis - pathology
Tomography, X-Ray Computed
Toxicity
Toxicity: respiratory system, ent, stomatology
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Summary:We report the case of a patient who was treated with amiodarone, developed an acute pneumonitis within 2 weeks, and succumbed to fatal pulmonary fibrosis despite treatment with corticosteriods. As the use of amiodarone expands, all physicians must be aware of the potential for amiodarone-related pulmonary (and otehr) toxicity and be aware of its nonspecific presentations.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(02)02213-0