Cardio embolic stroke and blood biomarkers: diagnosis and predictors of short-term outcome

• Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Psychiatry and Neurosurgery, 2019-12, Vol.55 (1), p.1-9
• Main Authors: Mohamed, Wafaa S, Abd ElGawad, Elhady A, ElMotayam, Amal SE, Fathy, Sabah E
• Format: Article
• Language: English
• Subjects: Biomarkers; Brain natriuretic peptide; Cardio-embolic stroke; Creatine kinase; D-dimer; Enzymes; Short term; Stroke
• ISSN: 1110-1083; 1687-8329
• DOI: 10.1186/s41983-019-0102-y

BackgroundThe brain is a productive source of a variety of enzymes and any brain injury like a stroke to brain tissue could similarly result in an increase in these enzymes in cerebrospinal fluid and serum. Evaluation of these enzymes represents a simple method for the ischemic stroke subtype diagnosis and prognosis. Objective: This study aimed to determine the role of brain natriuretic peptide (BNP), d-dimer, creatine–kinase-MB (CK-MB), C-reactive protein (CRP) serum levels, and globulin/albumin ratio in the diagnosis of CES stroke and its ability to predict short-term outcome.MethodsThis study was conducted on 96 patients with acute ischemic stroke, subdivided into two groups: group Ι was 48 patients with cardio-embolic stroke and group ΙΙ was 48 patients with non-cardio-embolic. All patients were subjected to the assessment of serum BNP, d-dimer and CK-MB, and CRP and globulin/albumin ratio within the first 24 h of stroke. In the third week, they were assessed by mRS.ResultsThe mean levels of BNP, d-dimer level, and CK-MB were significantly higher in patients with cardio-embolic stroke than in patients with non-cardio-embolic stroke (P