Later is better: Corticosteroids selectively suppress early memory T cells

Systemic corticosteroid therapy selectively affects low-affinity memory CD8 + T cells and may alter the efficacy of immune checkpoint blockade. Systemic corticosteroid therapy selectively affects low-affinity memory CD8 + T cells and may alter the efficacy of immune checkpoint blockade.

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Bibliographic Details
Published in:Science translational medicine 2019-10, Vol.11 (513)
Main Author: Kulkarni, Rajan P.
Format: Article
Language:English
Subjects:
CD8 antigen
Corticosteroids
Immune checkpoint
Immunological memory
Lymphocytes T
Memory cells
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Description
Summary:Systemic corticosteroid therapy selectively affects low-affinity memory CD8 + T cells and may alter the efficacy of immune checkpoint blockade. Systemic corticosteroid therapy selectively affects low-affinity memory CD8 + T cells and may alter the efficacy of immune checkpoint blockade.
ISSN:1946-6234
1946-6242
1946-3242
DOI:10.1126/scitranslmed.aaz3711