Glioblastoma in adults with neurofibromatosis type I: A report of two cases

Neurofibromatosis type I (NF1) is a familial tumor syndrome with an autosomal‐dominant inheritance. NF1‐associated tumors often include neurofibromas, malignant peripheral nerve sheath tumors and pilocytic astrocytomas of the optic nerve. The presentation of NF1 patients with glioblastoma is a rare...

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Bibliographic Details
Published in:Neuropathology 2019-10, Vol.39 (5), p.368-373
Main Authors: Narasimhaiah, Deepti, Sridutt, Bhaadri S, Thomas, Bejoy, Vilanilam, George C
Format: Article
Language:English
Subjects:
Adolescent
adult
Astrocytoma
Autosomal dominant inheritance
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Female
Genetic disorders
Glioblastoma
Glioblastoma - genetics
Glioblastoma - pathology
Heredity
Humans
Male
mutation
Neurofibromatosis
Neurofibromatosis 1 - complications
Neurofibromatosis 1 - pathology
Neurofibromatosis type I
Neurological disorders
NF1 gene
Optic nerve
Peripheral nerves
Tumors
Young Adult
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Summary:Neurofibromatosis type I (NF1) is a familial tumor syndrome with an autosomal‐dominant inheritance. NF1‐associated tumors often include neurofibromas, malignant peripheral nerve sheath tumors and pilocytic astrocytomas of the optic nerve. The presentation of NF1 patients with glioblastoma is a rare occurrence, with only a handful of cases reported in the literature. We report two cases of glioblastomas occurring in adults with NF1 and briefly review the relevant literature.
ISSN:0919-6544
1440-1789
DOI:10.1111/neup.12579