Green synthesis of new thiouracilodepsipeptides in ionic liquid: One‐pot four‐component reaction of isocyanides

Thiouracil‐containing depsipeptides were produced via one‐pot four‐component condensation/Passerini tandem reaction of thiouracil, 2‐chloroacetic acid derivatives, ketones, and isocyanides in ionic liquid as green reaction media in high yields. Combining synthetic potentialities of multicomponent re...

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Bibliographic Details
Published in:Journal of the Chinese Chemical Society (Taipei) 2019-10, Vol.66 (10), p.1375-1380
Main Author: Shahvelayati, Ashraf S.
Format: Article
Language:English
Subjects:
Cascade chemical reactions
Chloroacetic acid
depsipeptide
Ionic liquids
Ions
Ketones
multicomponent reactions
passerini reaction
tandem protocol
thiouracil
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Summary:Thiouracil‐containing depsipeptides were produced via one‐pot four‐component condensation/Passerini tandem reaction of thiouracil, 2‐chloroacetic acid derivatives, ketones, and isocyanides in ionic liquid as green reaction media in high yields. Combining synthetic potentialities of multicomponent reactions (MCRs) with the dual properties of ionic liquids (ILs) as solvents and catalysts results in the emergence of promising strategies for the growth of costly ecocompatible organic synthesis procedures. Here, we have reported a facile tandem protocol for the synthesis of thiouracilodepsipeptides from the reaction of thiouracil, 2‐chloroacetic acid derivatives, ketones, and isocyanides in ionic liquid as green media.
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.201800209