Utility of 3-(thiophen-2-yl)prop-2-enoyl isothiocyanate in heterocyclic synthesis

Convenient syntheses of quinazoline, benzothiazole, thiadiazole, imidazole, and thiourea derivatives starting from 3-(thiophen-2-yl)prop-2-enoyl isothiocyanate are described. The structures of the synthesized compounds are confirmed from their microanalytical and spectral data. Some of the products...

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Bibliographic Details
Published in:Journal of chemical research 2019-09, Vol.43 (9-10), p.307-312
Main Authors: El-Sayed, Amira A, Atta-Allah, Saad R, Hemdan, Magdy M
Format: Article
Language:English
Subjects:
Bacteria
Caustic soda
Fungi
Gram-negative bacteria
Gram-positive bacteria
Hydrochloric acid
Imidazole
Thiourea derivatives
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Summary:Convenient syntheses of quinazoline, benzothiazole, thiadiazole, imidazole, and thiourea derivatives starting from 3-(thiophen-2-yl)prop-2-enoyl isothiocyanate are described. The structures of the synthesized compounds are confirmed from their microanalytical and spectral data. Some of the products are examined for their antibacterial activity against Gram-positive and Gram-negative bacteria and fungi.
ISSN:1747-5198
2047-6507
DOI:10.1177/1747519819862176