APOE genotype status on the effect of residential greenness on cognitive function and mortality: a cohort study

Our study aimed to test whether the effects of residential greenness on cognitive function and mortality differ by APOE genotypes among Chinese adults aged 65 years and older. We used Chinese Longitudinal Healthy Longevity Survey data, a longitudinal cohort of individuals aged 65 years and older. We...

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Bibliographic Details
Published in:The Lancet (British edition) 2019-10, Vol.394, p.S73-S73
Main Authors: Ji, John S, Zhu, Anna, Shu, Chang, Jin, Xurui, Wu, Chih-Da, Yan, Lijing
Format: Article
Language:English
Subjects:
Adults
Apolipoprotein E
Cognitive ability
Cohort analysis
Genotype-environment interactions
Genotypes
Impairment
Mortality
Normalized difference vegetative index
Older people
Physical activity
Recreation
Smoking
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Summary:Our study aimed to test whether the effects of residential greenness on cognitive function and mortality differ by APOE genotypes among Chinese adults aged 65 years and older. We used Chinese Longitudinal Healthy Longevity Survey data, a longitudinal cohort of individuals aged 65 years and older. We calculated the normalised difference vegetation index (NDVI) using a 500 m radius around each participant's residence to reflect residential greenness. We used the Mini-Mental State Examination (MMSE) to measure cognitive function, and monitored survival status between 2000 and 2014. We categorised participants as APOE ɛ2 carriers, ɛ3/ɛ3 carriers, and ɛ4 carriers. We applied logistic regression to examine the association between baseline annual average NDVI, APOE genotypes, and cognitive impairment (reference group MMSE ≥24), and the Cox proportional hazard regression to assess the relationship between contemporaneous NDVI, APOE genotypes, and mortality. We adjusted for age, sex, ethnicity, marital status, urban or rural residence, education, occupation, financial status, social and leisure activity, smoking status, drinking status, physical activity, and geographic regions. We included 9156 participants with a mean age of 82·6 years (SD 11·8). 1302 (14·2%) participants were APOE ɛ2 carriers, 6254 (68·3%) were ɛ3/ɛ3 carriers, and 1600 (17·5%) were ɛ4 carriers. We observed a significant interaction between NDVI and APOE genotypes both for cognitive impairment (pinteraction=0·0025) and mortality (pinteraction
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(19)32409-2