Growth promoting activity in culture of spontaneous proliferating leukemic lymphocytes

It is shown that leukemic lymphocytes from the peripheral blood of bovine with chronic lymphocytic leukemia proliferate in the serum-free Eagle medium in the absence of exogenous growth factors and mitogenic stimulation. The nondializable, thermostable, trypsin sensitive growth promoting activity is...

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Bibliographic Details
Published in:Biopolimery i kletka 1988-11, Vol.4 (6), p.329-333
Main Authors: Kalvelyte, A. L., Pabrezaite, L. J., Valius, M. R., Konstantinavicius, K. V.
Format: Article
Language:English
Subjects:
Cell culture
Chronic lymphocytic leukemia
Growth factors
Lymphatic leukemia
Lymphocytes
Peripheral blood
Trypsin
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Summary:It is shown that leukemic lymphocytes from the peripheral blood of bovine with chronic lymphocytic leukemia proliferate in the serum-free Eagle medium in the absence of exogenous growth factors and mitogenic stimulation. The nondializable, thermostable, trypsin sensitive growth promoting activity is determined in the culture medium conditioned by leukemic cells. The results suggest that circulating leukemic lymphocytes are capable of elaborating growth factors to which they can respond.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.000241