PCR amplification, cloning and sequencing of cDNA fragment encoding a nucleotide binding domain of mammalian tyrosyl-tRNA synthetase

cDNA fragment encoding the N-terminal nucleotide binding domain (Rossmann fold) of mammalian tyrosyl-tRNA synthetase has been PCR-amplified, cloned and sequenced. The unique variant of conservative HIGH-like motif, HVA Y, where glycine residue was substituted by alanine, has been observed for the fi...

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Bibliographic Details
Published in:Biopolimery i kletka 1996, Vol.12 (5), p.66-71
Main Authors: Levanets, O. V., Naidenov, V. G., Woodmaska, M. I., Odynets, K. A., Matsuka, G. H., Kornelyuk, A. I.
Format: Article
Language:English
Subjects:
Alanine
Glycine
tRNA
Tyrosine-tRNA ligase
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Summary:cDNA fragment encoding the N-terminal nucleotide binding domain (Rossmann fold) of mammalian tyrosyl-tRNA synthetase has been PCR-amplified, cloned and sequenced. The unique variant of conservative HIGH-like motif, HVA Y, where glycine residue was substituted by alanine, has been observed for the first time.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.00044B