Olanzapine: The Game-Changer “Antiemetic”

Abstract Chemotherapy-induced nausea and vomiting (CINV) is significantly debilitating and worsens the quality of life. Olanzapine, an atypical antipsychotic drug, also has an antiemetic potential. Studies have shown that olanzapine-based regimens have similar efficacy as compared to aprepitant in p...

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Bibliographic Details
Published in:Indian journal of medical and paediatric oncology 2019-04, Vol.40 (2), p.274-276
Main Author: Dhanushkodi, Manikandan
Format: Article
Language:English
Subjects:
Anesthesia
Antipsychotic agents
Antipsychotics
Aprepitant
Bipolar disorder
Cancer
Cancer therapies
Cancer treatment
Carboplatin
Chemotherapy
Development and progression
Dexamethasone
Dosage and administration
Drug dosages
Drug Review
Glucocorticoids
Medical research
Nausea
Olanzapine
Palonosetron
Psychotropic drugs
Quality of life
Risk factors
Schizophrenia
Systematic review
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Summary:Abstract Chemotherapy-induced nausea and vomiting (CINV) is significantly debilitating and worsens the quality of life. Olanzapine, an atypical antipsychotic drug, also has an antiemetic potential. Studies have shown that olanzapine-based regimens have similar efficacy as compared to aprepitant in patients receiving highly emetogenic chemotherapy (HEC). National Comprehensive Cancer Network guidelines also recommends olanzapine-based regimen in HEC. Olanzapine, palonosetron, dexamethasone regimen is a cost-effective option in resource-limited settings in patients receiving HEC.
ISSN:0971-5851
0975-2129
DOI:10.4103/ijmpo.ijmpo_151_19