Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer

Background/Aim: The PRKCI gene encodes Protein kinase C iota. The overexpression of protein kinase C iota is associated with poor outcomes in patients with gastric and other cancers, but the role of the PRKCI gene in gastric cancer is not fully understood. Thus, we evaluated the clinical significanc...

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Bibliographic Details
Published in:Anticancer research 2019-10, Vol.39 (10), p.5715-5720
Main Authors: HASHIMOTO, ITARU, SAKAMAKI, KENTARO, OUE, NAOHIDE, KIMURA, YAYOI, HIROSHIMA, YUKIHIKO, HARA, KENTARO, MAEZAWA, YUKIO, KANO, KAZUKI, AOYAMA, TORU, YAMADA, TAKANOBU, YAMAMOTO, NAOTO, OGATA, TAKASHI, ITO, HIROYUKI, SHIOZAWA, MANABU, MORINAGA, SOICHIRO, RINO, YASUSHI, YASUI, WATARU, MASUDA, MUNETAKA, MIYAGI, YOHEI, OSHIMA, TAKASHI
Format: Article
Language:English
Subjects:
Cancer
Clinical significance
Gastrectomy
Gastric cancer
Gene expression
Kinases
Mucosa
Protein kinase C
Proteins
Tissues
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Summary:Background/Aim: The PRKCI gene encodes Protein kinase C iota. The overexpression of protein kinase C iota is associated with poor outcomes in patients with gastric and other cancers, but the role of the PRKCI gene in gastric cancer is not fully understood. Thus, we evaluated the clinical significance of PRKCI gene expression in gastric cancer. Materials and Methods: PRKCI mRNA expression levels in cancerous tissues and adjacent normal mucosa from 398 patients with gastric cancer were measured. Relationships between PRKCI gene expression and clinicopathological characteristics and outcomes were examined. Results: Overall survival was lower in patients with a high expression of PRKCI than in those with low expression (p=0.016). No other relationships were observed. A high PRKCI expression was found to be an independent prognostic factor (p=0.036, HR=1.44, 95%CI=1.02-2.02). Conclusion: PRKCI gene expression in cancerous tissue might be a useful prognostic factor in patients with gastric cancer after gastrectomy.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13771