Decreased H3K27me3 Expression Is Associated With Merkel Cell Polyomavirus-negative Merkel Cell Carcinoma, Especially Combined With Cutaneous Squamous Cell Carcinoma

Background/Aim: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, frequently infected with Merkel cell polyomavirus (MCPyV). H3K27me3 acts as a repressive histone modification that epigenetically controls gene transcription. The aim of this study was to examine H3K27me...

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Bibliographic Details
Published in:Anticancer research 2019-10, Vol.39 (10), p.5573-5579
Main Authors: MATSUSHITA, MICHIKO, IWASAKI, TAKESHI, WARDHANI, LUSI OKA, KUWAMOTO, SATOSHI, NONAKA, DAISUKE, NAGATA, KEIKO, KATO, MASAKO, KITAMURA, YUKISATO, HAYASHI, KAZUHIKO
Format: Article
Language:English
Subjects:
Cancer
Gene expression
Histology
Skin cancer
Squamous cell carcinoma
Transcription
Tumorigenesis
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Summary:Background/Aim: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, frequently infected with Merkel cell polyomavirus (MCPyV). H3K27me3 acts as a repressive histone modification that epigenetically controls gene transcription. The aim of this study was to examine H3K27me3 expression in MCC. Materials and Methods: H3K27me3 expression levels were immunohistochemically analyzed in 20 MCPyV-positive MCCs, 15 MCPyV-negative MCCs with squamous cell carcinoma (SCC) (combined MCCs), and six MCPyV-negative pure MCCs. Results: Reduced H3K27me3 expression was variously observed in MCCs. H3K27me3 H-score was significantly lower in MCPyV-negative MCCs than in MCPyV-positive MCCs (p=0.002). H3K27me3 expression was significantly lower in MCPyV-negative combined MCC component than in MCPyV-positive MCCs (p
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13751