A specific assay for JmjC domain-containing lysine demethylase and its application to inhibitor screening

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Bibliographic Details
Published in:Science China. Life sciences 2019-10, Vol.62 (10), p.1404-1408
Main Authors: Wen, He, Li, Guo, Chen, Yongcan, Li, Meiting, Lv, Yafei, Li, Zhiming, Li, Yinglu, Hou, Tianyun, Wang, Hui, Liu, Chaohua, Lu, Xiaopeng, Zhu, Qian, Bao, Yantao, Liu, Ge, Li, Xiaofan, Zhu, Wei-Guo
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biosensing Techniques
Chromatin - chemistry
Enzyme Inhibitors - chemistry
HeLa Cells
High-Throughput Screening Assays
Humans
Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors
Kinetics
Letter to the Editor
Life Sciences
Lysine
Magnetic Resonance Spectroscopy
Methylation
Molecular Structure
NAD - chemistry
Protein Binding
Protein Conformation
Sensitivity and Specificity
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ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-019-9582-9