Effect of chloroquine on experimental melanin-protein-induced uveitis in Lewis rats

To evaluate the effect of chloroquine on experimental recurrent autoimmune melanin-protein-induced uveitis in Lewis rats. Five Lewis rats were immunized with melanin to induce uveitis (group I); another six were immunized and treated with 5 mg/kg/day of chloroquine (group II). To reinduce uveitis, t...

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Published in:Graefe's archive for clinical and experimental ophthalmology 1999-09, Vol.237 (9), p.775-780
Main Authors: QUIROZ-MERCADO, H, CEDILLO-LEY, M, RODRIGUEZ-REYES, A, CORTEZ-GONZALEZ, R, ARELLANES-GARCIA, L, ORTEGA-LARROCEA, G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cattle
Chloroquine - pharmacology
Female
Fluorescein Angiography
Immunomodulators
Medical sciences
Melanins - biosynthesis
Ophthalmology
Pharmacology. Drug treatments
Rats
Rats, Inbred Lew
Secondary Prevention
Time Factors
Uveitis - diagnosis
Uveitis - metabolism
Uveitis - pathology
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Summary:To evaluate the effect of chloroquine on experimental recurrent autoimmune melanin-protein-induced uveitis in Lewis rats. Five Lewis rats were immunized with melanin to induce uveitis (group I); another six were immunized and treated with 5 mg/kg/day of chloroquine (group II). To reinduce uveitis, they received two booster injections of melanin. They were killed when uveitis was present after the last booster injection; every eye was evaluated by means of clinical and histopathological examination. A control group of four rats received the same chloroquine dose to evaluate retinal toxicity (group III). Rats in group I showed more severe uveitis episodes than rats in group II. The second uveitis episode was more severe in group I than in group I. Rats in group III showed no clinical or histopathological abnormalities. Chloroquine decreased the severity and duration of uveitis, and in two rats it prevented recurrences. Thus, chloroquine can be considered an effective treatment for chronic, recurrent experimental uveitis.
ISSN:0721-832X
1435-702X
DOI:10.1007/s004170050311