Orbital invasion despite topical anti-metabolite therapy for conjunctival carcinoma

Background Two cases of conjunctival carcinoma developed orbital invasion during treatment with topical medication. Methods This was a retrospective study from a tertiary ophthalmic oncology unit, performed after informed consent was obtained. The main outcome measurement was orbital invasion. Resul...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2008-03, Vol.246 (3), p.459-461
Main Authors: Char, Devron H., Crawford, J. Brooks
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Aged
Antimetabolites, Antineoplastic - therapeutic use
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - secondary
Case Report
Conjunctival Neoplasms - drug therapy
Conjunctival Neoplasms - pathology
Fluorouracil - therapeutic use
Humans
Interferon-alpha - therapeutic use
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Mitomycin - therapeutic use
Neoplasm Recurrence, Local - diagnosis
Ophthalmology
Orbital Neoplasms - diagnosis
Orbital Neoplasms - secondary
Recombinant Proteins
Retrospective Studies
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Summary:Background Two cases of conjunctival carcinoma developed orbital invasion during treatment with topical medication. Methods This was a retrospective study from a tertiary ophthalmic oncology unit, performed after informed consent was obtained. The main outcome measurement was orbital invasion. Results Two patients treated with topical agents developed orbital invasion. Conclusion While topical agents are important in treatment of conjunctival neoplasia, recurrence or deep invasion require careful monitoring.
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-007-0742-y