Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives

Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[ f, h ]pyrimido[4′,5′:4,5]thieno[2,3- c ]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[ f, h ]-pyrimido[4′,5′:4,5]thieno[2,3- c ]cinnoline. Reactions of the latter with mor...

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Bibliographic Details
Published in:Russian journal of general chemistry 2019-09, Vol.89 (9), p.1887-1895
Main Authors: Fayed, A. A., Alahmadi, Y. M., Yousif, M. N. M., Yousif, N. M., Amer, A. A., El-Farargy, A. F., Ouf, N. H., Gad, F. A.
Format: Article
Language:English
Subjects:
Aldehydes
Anti-arrhythmia drugs
Anti-inflammatory drugs
Antiviral agents
Aromatic compounds
Avian influenza
Avian influenza viruses
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Malononitrile
Morpholine
Piperidine
Pyrimidines
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Summary:Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[ f, h ]pyrimido[4′,5′:4,5]thieno[2,3- c ]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[ f, h ]-pyrimido[4′,5′:4,5]thieno[2,3- c ]cinnoline. Reactions of the latter with morpholine, piperidine, malononitrile, phenylbromide, aromatic aldehydes, and ethyl cyanoacetate have been studied. Some synthesized compounds have been subjected to further transformations. The synthesized pyrimidinothienocinnoline derivatives are tested for their anti-inflammatory activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219090251