Drug Interactions in Elderly People Making use of oral Anticoagulants and Hospitalized in a Cardiology Hospital

• Published in: Revista de pesquisa, cuidado é fundamental cuidado é fundamental, 2019-10, Vol.11 (5), p.1312-1318
• Main Authors: Cheno, Maysa Yukari, Cardilli, Carolina Vieira Cagnacci, Kobayashi, Rika Miyahara
• Format: Article
• Language: English
• Subjects: Anticoagulants; Cardiology; Hospitalization; Internet; Mortality; Older people; Polypharmacy; Thromboembolism
• ISSN: 2175-5361
• DOI: 10.9789/2175-5361.2019.v11i5.1312-1318

Conclusion: Polypharmacy and the use of oral anticoagulants in elderly patients bearing heart diseases are common events. [...]a better understanding about drug interactions is also required, bearing in mind that they can either potentialize or decrease the anticoagulant effect, with high or moderate severity. [...]it is not possible to say with certainty if it was a drug interaction or not, since there are several factors that may have caused them. [...]in this study, we will refer to drug interactions as "potential". In this study, the combination of Paracetamol and Codeine was prescribed only twice and for two patients, but it was not known whether the prescriber and those who took and administered had knowledge about the potential drug interaction or was actually a risk-benefit assessment. [...]Paracetamol is a Nonsteroidal Anti-Inflammatory Drug (NSAID) with an analgesic and antipyretic effect, widely used domestically.36 It is known from clinical practice that its concomitant use of Warfarin can cause considerable damage, such as bleeding. [...]if necessary, it is possible to change the OAC dose at the time of its administration.34,35 CONCLUSIONS Warfarin is an oral vitamin K antagonist with action duration of about two to five days and usually of continuous use. [...]prolonged action.