Bioactivity-Guided Isolation of Anti-Inflammatory Principles from Cistus parviflorus Lam

Bioactivity-guided fractionation and purification of Cistus parviflorus led to the isolation of two flavan-3-ol derivatives; gallocatechin (1) and epigallocatechin (2) and two flavonoid glycosides; avicularin (3) trans-tiliroside (4). The structures of the compounds were elucidated on the basis of N...

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Bibliographic Details
Published in:Records of natural products 2019-05, Vol.13 (3), p.226-235
Main Authors: Gürbüz, Perihan, Doğan, Şengül Dilem, Çelik, Gizem Nur, Bekci, Hatice, Cumaoğlu, Ahmet, Gündüz, Miyase Gözde, Paksoy, Mehmet Yavuz
Format: Article
Language:English
Subjects:
Biological activity
Flavonoids
Molecules
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Summary:Bioactivity-guided fractionation and purification of Cistus parviflorus led to the isolation of two flavan-3-ol derivatives; gallocatechin (1) and epigallocatechin (2) and two flavonoid glycosides; avicularin (3) trans-tiliroside (4). The structures of the compounds were elucidated on the basis of NMR and ESIMS data. All compounds were isolated from C. parviflorus for the first time. Compounds 2 and 3 exhibited anti-inflammatory activity through decreasing the NOS2 and COX2 levels on LPS+IFN-γ treated RAW 264.7 cells. Molecular docking studies of avicularin, the most potent compound, were carried out in the active sites of NOS2 and COX2 to predict the most plausible binding modes and support the experimental data.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.106.18.09.883