Polyacetylenes from the Roots of Aralia dumetorum

A new polyacetylene, heptadeca-8,16-dien-4,6-diyn-3,l0-diol (1) along with four known polyacetylenes, 1,2-dihydrodendroarboreol B (2), heptadeca-1,8-dien-4,6-diyn-3,l0-diol (3), 3R, 8S-falcarindiol (4) and 3R,8R-dehydrofalcarindiol (5) were isolated from the ethanol extract of Aralia dumetorum. The...

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Bibliographic Details
Published in:Records of natural products 2019-09, Vol.13 (5), p.424-428
Main Authors: Jiang, Meng-Yuan, Yang, Chun-Tao, Pu, Xiao-Yun, Fu, Guangmiao, Wang, Wei, Li, Yu-Xiao, Feng, Lei, Niu, hi-Rui, Tan, Jian-Lin, Huang, Xiang-Zhong
Format: Article
Language:English
Subjects:
Chemical compounds
Glucose
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Summary:A new polyacetylene, heptadeca-8,16-dien-4,6-diyn-3,l0-diol (1) along with four known polyacetylenes, 1,2-dihydrodendroarboreol B (2), heptadeca-1,8-dien-4,6-diyn-3,l0-diol (3), 3R, 8S-falcarindiol (4) and 3R,8R-dehydrofalcarindiol (5) were isolated from the ethanol extract of Aralia dumetorum. The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectrums and by comparison of the spectroscopic data with those reported for structurally related compounds. The α-glucosidase inhibitory activity of compounds 1-5 was evaluated using α-glucosidase inhibitory assay, in which all compoundsdisplayed good inhibitory activity with IC50 values ranging from 4.2 ~ 36.2 μM.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.119.18.09.940