New Cytotoxic Metabolites from Pathogenic Fungus Cylindrocarpon destructans Associated with Meconopsis grandis

Phytochemical investigation on pathogenic fungus Cylindrocarpon destructans isolated form Meconopsisgrandis plant led to the isolation of two new isochromene derivatives namely, 6,8-dimethoxy-3-methyl-3,4-dihydrobenzoisochromene-4,9,10-triol (1) and 3,5,6-trihydroxy-4-methylbenzoisochromene-9,11-dio...

Full description

Saved in:
Bibliographic Details
Published in:Records of natural products 2019-03, Vol.13 (2), p.129-135
Main Authors: Khan, Dilfaraz, Niaz, Shah Iram, Tahir, Kamran, Khan, Hidayat Ullah, Haroon, Muhammad, Khan, Shahid Ullah, Badshah, Syed, Khan, Shafiullah, Jabeen, Muafia, Lan, Liu
Format: Article
Language:English
Subjects:
Chemistry
Cytotoxicity
Fungi
Pathogens
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phytochemical investigation on pathogenic fungus Cylindrocarpon destructans isolated form Meconopsisgrandis plant led to the isolation of two new isochromene derivatives namely, 6,8-dimethoxy-3-methyl-3,4-dihydrobenzoisochromene-4,9,10-triol (1) and 3,5,6-trihydroxy-4-methylbenzoisochromene-9,11-dione (2) along with four known compounds (3-6). The structures of these compounds were elucidated by 1D and 2D NMR and mass spectroscopic data analysis. The isolated compounds were evaluated for cytotoxic activity. The compounds 1-4 showed good inhibition against the growth of cell lines MCF-7 and PC-3. Compounds 5-6 showed minimum inhibitory effect of cancerous cell lines growth.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.67.18.01.207