Designing Molecular Building Blocks for Functional Polymersomes

In recent years various polymeric vesicles have been reported that show promising results for drug delivery applications, nanomotors and/or nanoreactors. These polymeric vesicles can be assembled from many different materials and various coupling reactions have been applied for functionalization of...

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Bibliographic Details
Published in:Israel journal of chemistry 2019-10, Vol.59 (10), p.928-944
Main Authors: Rijpkema, Sjoerd J., Toebes, B. Jelle, Maas, Marijn N., Kler, Noël R. M., Wilson, Daniela A.
Format: Article
Language:English
Subjects:
Biomedical materials
Block copolymers
Block-Copolymer
Chemical reactions
Complex systems
Coupling (molecular)
Drug delivery systems
Functional Handle
Functionalization
Nanoparticles
Nanotechnology devices
Nanovesicle
Polymersome
Properties (attributes)
Vesicles
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Summary:In recent years various polymeric vesicles have been reported that show promising results for drug delivery applications, nanomotors and/or nanoreactors. These polymeric vesicles can be assembled from many different materials and various coupling reactions have been applied for functionalization of the vesicles. However, the designs reported are still rather simple, as it is challenging to mimic biological complex systems. In this review we focus on the properties of widely used hydrophobic polymers to better understand polymersome properties for various applications. Examples are shown of how researchers have used and modulated block‐copolymers and their properties to their advantage. Furthermore, an overview of possible end group functionalizations of nanoparticles is reported, giving insight in recent developments of smart nanoparticles for biomedical applications.
ISSN:0021-2148
1869-5868
DOI:10.1002/ijch.201900039