Prochlorperazine Maleate Loaded Sustained Release Floating Microspheres prepared by lonotropic Gelation Technique: Morphology and Release Characteristics

Once a daily oral sustained release microsphere based floating formulation of Prochlorperazine Maleate (PCZM) was prepared with intent of reduction in frequency of administration which will increase the bioavailability and further to enhance the patient compliance thus avoiding treatment failure. Fo...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2019-08, Vol.12 (8), p.3866-3872
Main Authors: Pawashe, Pallavi M, Patil, Shital Kumar S, Naikwade, Nilofar S
Format: Article
Language:English
Subjects:
Acids
Bioavailability
Cellulose
Chloride
Drug delivery systems
Drug dosages
Drug stores
Efficiency
Morphology
Patient compliance
Pharmaceutical sciences
Pharmacy
Polymers
Polymethyl methacrylate
Psychotropic drugs
R&D
Research & development
Sodium
Stomach
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Summary:Once a daily oral sustained release microsphere based floating formulation of Prochlorperazine Maleate (PCZM) was prepared with intent of reduction in frequency of administration which will increase the bioavailability and further to enhance the patient compliance thus avoiding treatment failure. For treatment of vommiting and nausea, PCZM is a drug of choice. PCZM, phenothiazine antipsychotic, has low biological half life and required multiple dosing frequency (3-4 times daily). Ionotropic gelation technique was used to prepare a sustained release floating microsphere using calcium chloride as complexing agent, sodium alginate release retarding agent, and sodium bicarbonate as gas generation mediator. Different formulation batches Fl to F7 were prepared andevaluated for percent yield, entrapment efficiency, micrometric properties, floating lag time, total floating time and In-vitro dissolution study. Optimized formulation batch F6was subjected for physical characterization and morphological study like DSC, PXRD, FTIR and SEM respectively. Results of In-vitro dissolution study of optimized formulation batch F6 showed sustained release property with floating characteristic of PCZM microspheres for more than 24 hrs. Release study of Optimized formulation F6 followed Korsmeyer's Peppas model release kinetics with non-fickian diffusion. SEM study revealed spherical shape of the microspheres with rough and porous surface.
ISSN:0974-3618
0974-306X
DOI:10.5958/0974-360X.2019.00664.4