Plant-derived chlorophyll derivative loaded liposomes for tri-model imaging guided photodynamic therapy

Plant-derived chlorophyll derivatives with a porphyrin ring structure and intrinsic photosynthesis have been widely used in biomedicine for cancer theranostics. Owing to their poor water solubility, chlorophyll derivatives are very difficult to use in biomedical applications. In this work, pyropheop...

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Bibliographic Details
Published in:Nanoscale 2019-11, Vol.11 (42), p.19823-19831
Main Authors: Zhou, Hailin, Xia, Lu, Zhong, Jing, Xiong, Saisai, Yi, Xuan, Chen, Lei, Zhu, Ran, Shi, Quanliang, Yang, Kai
Format: Article
Language:English
Subjects:
Animals
Biomedical materials
Blood circulation
Cancer
Cell Line, Tumor
Chlorophyll
Chlorophyll - chemistry
Chlorophyll - pharmacology
Computed tomography
Contrast agents
Derivatives
Female
Fluorescence
Liposomes
Mammary Neoplasms, Experimental - diagnostic imaging
Mammary Neoplasms, Experimental - drug therapy
Medical imaging
Mice
Mice, Inbred BALB C
Nanoparticles
Near infrared radiation
Photochemotherapy
Photodynamic therapy
Photosynthesis
Radiolabelling
Ring structures
Single Photon Emission Computed Tomography Computed Tomography
Solubility
Water circulation
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Summary:Plant-derived chlorophyll derivatives with a porphyrin ring structure and intrinsic photosynthesis have been widely used in biomedicine for cancer theranostics. Owing to their poor water solubility, chlorophyll derivatives are very difficult to use in biomedical applications. In this work, pyropheophorbide acid (PPa) (liposome/PPa) nanoparticles, a liposome-encapsulated chlorophyll derivative, are designed for tri-model imaging guided photodynamic therapy (PDT) of cancer. The obtained liposome/PPa nanoparticles significantly enhance the water solubility of PPa, prolong blood circulation and optimize the bio-distribution in mice after intravenous injection. Utilizing their intrinsic fluorescence, high near-infrared (NIR) absorbance and extra radiolabeling, liposome/PPa nanoparticles could be used as excellent contrast agents for multimodal imaging including fluorescence (FL) imaging, photoacoustic (PA) imaging and SPECT/CT imaging. Under 690 nm laser irradiation at a low power density, liposome/PPa nanoparticles significantly inhibit tumor growth, further demonstrating the therapeutic efficiency of PDT using PPa. Therefore, our work developed liposome/PPa nanoparticles as multifunctional nanoagents for multimodal imaging guided PDT of cancer. This will further prompt the clinical applications of PPa in the future. In this work, a liposome-encapsulated chlorophyll derivative pyropheophorbide acid (PPa) (liposome/PPa) nanoparticles are designed for tri-model imaging guided photodynamic therapy (PDT) of cancer.
ISSN:2040-3364
2040-3372
DOI:10.1039/c9nr06941k