Genomic diversity among Vibrio cholerae O139 strains isolated in Bangladesh and India between 1992 and 1998

Abstract In order to assess the extent of genomic diversity among Vibrio cholerae O139 strains, restriction fragment length polymorphisms in two genetic loci, rrn and ctx, were studied. Analysis of 144 strains isolated from different regions of Bangladesh and India between 1992 and 1998 revealed the...

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Bibliographic Details
Published in:FEMS microbiology letters 2000-03, Vol.184 (2), p.279-284
Main Authors: Faruque, Shah M., Saha, Manujendra N., Asadulghani, Bag, Prasanta K., Bhadra, Rupak K., Bhattacharya, S.K., Sack, R.Bradley, Takeda, Yoshifumi, Nair, G.Balakrish
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobial resistance
Bacterial Typing Techniques
Bacteriology
Bangladesh - epidemiology
Biological and medical sciences
Cholera - epidemiology
Cholera - microbiology
Cholera Toxin - genetics
CTX genotype
DNA Restriction Enzymes
Drug resistance
Drug Resistance, Microbial
Fundamental and applied biological sciences. Psychology
Genes, rRNA
Genetic diversity
Genetic Variation
Genotypes
Humans
India - epidemiology
Microbial Sensitivity Tests
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pathogens
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Restriction Mapping
Ribotype
RNA, Ribosomal - genetics
Strains (organisms)
Vibrio cholerae
Vibrio cholerae - classification
Vibrio cholerae - drug effects
Vibrio cholerae - genetics
Vibrio cholerae - isolation & purification
Vibrio cholerae O139
Waterborne diseases
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Summary:Abstract In order to assess the extent of genomic diversity among Vibrio cholerae O139 strains, restriction fragment length polymorphisms in two genetic loci, rrn and ctx, were studied. Analysis of 144 strains isolated from different regions of Bangladesh and India between 1992 and 1998 revealed the presence of at least six distinct ribotypes (B-I through B-VI) of which three were new ribotypes, and one of these was represented by a nontoxigenic O139 strain. Strains of ribotypes B-I through B-V shared 11 different CTX genotypes (A through K). Antimicrobial resistance patterns of the strains varied independently of their ribotypes and CTX genotypes. Results of this study suggest that V. cholerae O139 is undergoing rapid genetic changes leading to the origination of new variants, and temporal changes in antimicrobial resistance patterns may be contributing to the selection of different variants.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2000.tb09027.x